Lighthouse Lab Services is representing a clinical laboratory with an immediate need for an experienced Medicinal Chemist. This lab is building a Drug Discovery team whose mission is to develop life-changing targeted therapies for cancer patient populations that are poorly treated by existing treatments. They are seeking a Medicinal Chemist with a proven track record of success in small/macromolecule drug discovery who is passionate about leading from the bench to solve medicinal chemistry challenges.


  • Drive the team forward with new medicinal chemistry analogs that consistently move the project toward the next breakthrough drug candidate.

  • Optimize lead series for potency, selectivity, physicochemical properties, in vitro ADME, and PK by coupling multivariant SAR analysis with hypothesis-driven medicinal chemistry design principles.

  • Use sound scientific methods to propose hypotheses and determine the next steps, even with complex or ambiguous data.

  • Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.

  • Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification, and characterization techniques.

  • Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.

  • Provide medicinal chemistry insight for a new target and lead identification and evaluation initiatives in the oncology space.

  • Proactively investigate new or different technologies to improve the effectiveness of the drug discovery process.

Preferred Candidate Profile

  • Ph.D. in Medicinal Chemistry with a focus on synthetic organic chemistry.

  • 3+years of experience in small molecule and bioconjugate drug discovery in a biotechnology or pharmaceutical/Academia setting.

  • Proven track record of success in advancing programs from leads to advanced candidates.

  • Strong project planning and problem-solving skills and capable of handling multiple projects under strict timelines

  • Extensive experience in lead compound optimization for potency, selectivity, ADME, and PK.

  • Experienced in the use of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.

  • Expert in using common medicinal chemistry software: electronic notebook, ChemDraw, Excel; Docking program data visualization; structure viewing; literature, chemical and database searching.

  • Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through the continued reading of the literature and attendance of scientific conferences.

  • An excellent team player with ability to communicate synergistically with a multi-disciplinary team and be accountable for the medicinal chemistry progress of the project. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.

  • Prepared scientific reports for grant proposals, publications and product license applications.

  • Exceptional interpersonal and communication skills, and ability to effectively present data within the company and to other stakeholders.

– Competitive Salary (based on experience)
– Health, Vision and Dental coverage
– PTO/vacation
About Us:

At Lighthouse Lab Services, we offer solutions to help start, grow, and run clinical laboratories. Our recruiting team has over 16 years of proven success placing job seekers in positions ranging from entry level Medical Technologists to seasoned Laboratory Directors. We recruit nationwide, for permanent and travel positions with clients ranging from small hospitals to large reference laboratories.

It is the policy of Lighthouse Lab Services to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. Lighthouse Lab Services is committed to working and providing reasonable accommodation to individuals of all abilities, including persons with disabilities. If at any time during the application process, you need an accommodation, please contact recruiting@lighthouselabservices.com for assistance.

Lighthouse Lab Services | 800-838-0602 | lighthouselabservices.com

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