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Principal Scientist, Histopathology
  • Location: Irvine, CA
  • Type: Direct Hire
  • Job #14474

Lighthouse is in search of a Principal Scientist, Histopathology based near Irvine, CA. As a member of our team, you will direct clinical, non-clinical, and internal research projects, troubleshoot laboratory assays and develop new assays, and provide technical oversight for all aspects of the study, and provide scientific feedback to clients. The ideal candidates will be proficient in histology and immunohistochemistry (IHC), experience directing projects, and communicating with clients.


  • Demonstrate an in-depth knowledge and expert understanding of the underlying technology.
  • Provide scientific and technical oversight for all aspects of the study, including interpretation, analysis and documentation of results.
  • Assure that all protocol amendments and deviations are documented and properly approved internally and by the sponsor.
  • Participate in calls, videoconferences and meetings with sponsors, clinical trial site personnel, quality assurance auditors, and regulatory inspectors.
  • Lead presentations for clients.
  • Ensure that the study is properly conducted in compliance with the study protocol.
  • Work with project management team to ensure projects are completed on time.
  • Review study data to ensure that it is of high quality, identify any potential concerns, investigate and resolve.
  • Prepare, review or contribute to study reports. Prepare, sign and approve the final study report to indicate acceptance for responsibility and validity of the data.
  • Interact with clients to sell our services, design studies, and develop study protocols.
  • Ensure response to QA department audits and that any findings are addressed properly.
  • Follow procedures in accordance with relevant GLP, GCP, CLIA and state laws and guidelines.
  • Maintain a work culture which is focused on customer service, the highest quality results and meeting deadlines.
  • Take an active role in advancing the company’s overall goals, objectives and growth.


  • M.S. or Ph.D. degree in the sciences with the ability and experience to fulfill the job description
  • Experience working in a GLP or CLIA laboratory.
  • Competent in histology and immunohistochemistry (IHC). Must be able to direct projects using these technologies, communicate results to clients and troubleshoot.
  • Subject matter expert in histology, IHC, FISH, ISH, immunofluorescence and image analysis.
  • Having the ability to identify cancer and normal cell types under a microscope.
  • Knowledge of immune cell phenotype markers (e.g. CD3, CD20) is preferred.
  • Having knowledge of methods of processing cancer tissue, cell culture related assays, and molecular assays.
  • 2+ years of experience managing projects for pharmaceutical or biotech companies and meeting deadlines.
  • Successful completion of a background check


  • Full-time; day shift; Monday – Friday from 9:30AM-6:00PM.

We care about our team and offer a wide range of benefits including:

  • Competitive wages
  • Medical, dental, and vision benefits
  • Life/AD&D benefits
  • Additional voluntary benefits
  • 401k retirement savings plan with a healthy match
  • Vacation and sick time
  • Career development opportunities
  • Continuing education
  • Free snacks

About Us:
At Lighthouse Lab Services, we offer solutions to help start, grow, and run clinical laboratories. Our recruiting team has over 17 years of proven success placing job seekers in positions ranging from entry level Medical Technologists to seasoned Laboratory Directors. We recruit nationwide, for permanent and travel positions with clients ranging from small hospitals to large reference laboratories.

 It is the policy of Lighthouse Lab Services to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, Lighthouse Lab Services will provide reasonable accommodations for qualified individuals with disabilities.

Lighthouse Lab Services | 800-838-0602 | lighthouselabservices.com

#JY #14474

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